Brentford’s three consecutive league wins were interrupted by a draw with Leeds United in the 21st matchday, keeping them in the top half of the standings.
The Bees aim for their third straight home win and are considered favorites by bookmakers against the visiting Saints, threatened by relegation.
Jansson and Onyeka are out with injuries while Baptiste is expected to play in Saturday’s match.
Southampton is hoping to continue their momentum from their FA Cup win over Blackpool.
However, the team has already suffered seven road losses this season and is unlikely to disrupt Brentford’s home game.
In their previous meeting at Brentford, the Bees won 3-0, and a similar outcome is expected. The away team will be without Larios and Livramento due to injuries.