| 2023-05-08 20:00:00May 8, 2023 |  Nottingham Forest vs Southampton | 4 - 3 | Premier League | 2022-2023 | The City Ground |
| 2023-04-30 14:00:00April 30, 2023 | Newcastle vs Southampton | 3 - 1 | Premier League | 2022-2023 | St. James' Park |
| 2023-04-27 19:45:00April 27, 2023 | Southampton vs Bournemouth | 0 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-04-21 20:00:00April 21, 2023 | Arsenal vs Southampton | 3 - 3 | Premier League | 2022-2023 | Emirates Stadium |
| 2023-04-15 15:00:00April 15, 2023 | Southampton vs Crystal Palace | 0 - 2 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-04-08 17:30:00April 8, 2023 | Southampton vs Manchester City | 1 - 4 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-04-02 14:00:00April 2, 2023 | West Ham vs Southampton | 1 - 0 | Premier League | 2022-2023 | London Stadium |
| 2023-03-18 16:00:00March 18, 2023 | Southampton vs Tottenham | 3 - 3 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-03-15 20:30:00March 15, 2023 | Southampton vs Brentford | 0 - 2 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-03-12 15:00:00March 12, 2023 | Manchester United vs Southampton | 0 - 0 | Premier League | 2022-2023 | Old Trafford |
| 2023-03-04 18:30:00March 4, 2023 | Southampton vs Leicester City | 1 - 0 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-02-25 16:00:00February 25, 2023 | Leeds vs Southampton | 1 - 0 | Premier League | 2022-2023 | Elland Road |
| 2023-02-18 16:00:00February 18, 2023 | Chelsea vs Southampton | 0 - 1 | Premier League | 2022-2023 | Stamford Bridge |
| 2023-02-11 16:00:00February 11, 2023 | Southampton vs Wolves | 1 - 2 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-02-04 16:00:00February 4, 2023 | Brentford vs Southampton | 3 - 0 | Premier League | 2022-2023 | Brentford Community Stadium |
| 2023-01-24 21:00:25January 24, 2023 | Southampton vs Newcastle | 0 - 1 | EFL CUP | 2022-2023 | |
| 2023-01-21 16:00:00January 21, 2023 | Southampton vs Aston Villa | 0 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2023-01-14 16:00:00January 14, 2023 | Everton vs Southampton | 1 - 2 | Premier League | 2022-2023 | Goodison Park |
| 2023-01-04 20:30:00January 4, 2023 | Southampton vs Nottingham Forest | 0 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-12-31 16:00:00December 31, 2022 | Fulham vs Southampton | 2 - 1 | Premier League | 2022-2023 | Craven Cottage |
| 2022-12-26 16:00:00December 26, 2022 | Southampton vs Brighton | 1 - 3 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-11-12 03:00:00November 12, 2022 | Liverpool vs Southampton | 3 - 1 | Premier League | 2022-2023 | Anfield |
| 2022-11-05 03:00:00November 5, 2022 | Southampton vs Newcastle | 1 - 4 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-10-29 03:00:00October 29, 2022 | Crystal Palace vs Southampton | 1 - 0 | Premier League | 2022-2023 | Selhurst Park |
| 2022-10-22 03:00:00October 22, 2022 | Southampton vs Arsenal | 1 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-10-18 07:45:00October 18, 2022 | Bournemouth vs Southampton | 0 - 1 | Premier League | 2022-2023 | Vitality Stadium |
| 2022-10-15 03:00:00October 15, 2022 | Southampton vs West Ham | 1 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-10-08 03:00:00October 8, 2022 | Manchester City vs Southampton | 4 - 0 | Premier League | 2022-2023 | Etihad Stadium |
| 2022-10-07 01:45:54October 7, 2022 | Southampton vs Fulham | 0 - 2 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-10-07 01:45:49October 7, 2022 | Brighton vs Southampton | 3 - 1 | Premier League | 2022-2023 | Amex Stadium |
| 2022-10-07 01:45:48October 7, 2022 | Southampton vs Liverpool | 4 - 4 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-10-01 03:00:00October 1, 2022 | Southampton vs Everton | 1 - 2 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-09-17 03:00:00September 17, 2022 | Aston Villa vs Southampton | 1 - 0 | Premier League | 2022-2023 | Villa Park |
| 2022-09-03 03:00:00September 3, 2022 | Wolves vs Southampton | 1 - 0 | Premier League | 2022-2023 | Molineux Stadium |
| 2022-08-31 07:45:00August 31, 2022 | Southampton vs Chelsea | 2 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-08-27 03:00:00August 27, 2022 | Southampton vs Manchester United | 0 - 1 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-08-20 03:00:00August 20, 2022 | Leicester City vs Southampton | 1 - 2 | Premier League | 2022-2023 | King Power Stadium |
| 2022-08-13 03:00:00August 13, 2022 | Southampton vs Leeds | 2 - 2 | Premier League | 2022-2023 | St. Mary's Stadium |
| 2022-08-06 03:00:00August 6, 2022 | Spurs vs Southampton | 4 - 1 | Premier League | 2022-2023 | Tottenham Hotspur Stadium |
